| No. | Game | Platform | Sales |
| 1 | Tetris † | GB | 35,000,000 |
| 2 | Pokémon Red, Green and Blue | GB | 31,380,000 |
| 3 | Pokémon Gold and Silver | GBC | 23,100,000 |
| 4 | Super Mario Land | GB | 18,140,000 |
| 5 | Pokémon Yellow | GB | 14,640,000 |
| 6 | Super Mario Land 2: 6 Golden Coins | GB | 11,180,000 |
| 7 | Pokémon Crystal | GBC | 6,390,000 |
| 8 | Dr. Mario | GB | 5,340,000 |
| 9 | Pokémon Pinball | GBC | 5,310,000 |
| 10 | Wario Land: Super Mario Land 3 | GB | 5,190,000 |
| 11 | Kirby's Dream Land | GB | 5,130,000 |
| 12 | Super Mario Bros. Deluxe | GBC | 5,070,000 |
| 13 | The Legend of Zelda: Oracle of Seasons and Oracle of Ages | GBC | 3,960,000 |
| 14 | Donkey Kong Land | GB | 3,910,000 |
| 15 | The Legend of Zelda: Link's Awakening † | GB | 3,830,000 |
| 16 | Pokémon Trading Card Game | GBC | 3,720,000 |
| 17 | F-1 Race | GB | 3,410,000 |
| 18 | Yoshi | GB | 3,120,000 |
| 19 | Donkey Kong | GB | 3,070,000 |
| 20 | Yu-Gi-Oh! Duel Monsters 4: Battle of Great Duelists | GBC | 2,500,000 |
| 21 | Kirby's Dream Land 2 | GB | 2,360,000 |
| 22 | Donkey Kong Land 2 | GB | 2,350,000 |
| Dragon Warrior Monsters | GBC | 2,350,000 | |
| 24 | The Legend of Zelda: Link's Awakening DX | GBC | 2,220,000 |
| 25 | Wario Land 3 | GBC | 2,200,000 |
| 26 | Donkey Kong Country | GBC | 2,190,000 |
| Kirby's Pinball Land | GB | 2,190,000 | |
| 28 | Golf | GB | 2,120,000 |
| 29 | Tennis | GB | 1,990,000 |
| 30 | Alleyway | GB | 1,940,000 |
Top 30 List of Best-selling Game Boy Video Games（GB GBC）
